New TFII-I family target genes involved in embryonic development

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New TFII-I family target genes involved in embryonic development.

Two members of the TFII-I family transcription factor genes, GTF2I and GTF2IRD1, are the prime candidates responsible for the craniofacial and cognitive abnormalities of Williams syndrome patients. We have previously generated mouse lines with targeted disruption of Gtf2i and Gtf2ird1. Microarray analysis revealed significant changes in the expression profile of mutant embryos. Here we describe...

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ژورنال

عنوان ژورنال: Biochemical and Biophysical Research Communications

سال: 2009

ISSN: 0006-291X

DOI: 10.1016/j.bbrc.2009.06.045